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AM-FM Laboratory


The Autism and Functional Mapping Laboratory (AM-FM) at the Olin Neuropsychiatry Research Center studies the neural network architecture of social-emotional processes, including social cognition and emotion regulation. By using cognitive neuroscience and advanced neuroimaging methods such as functional MRI (fMRI) we can explore these facets in typically developed individuals and in individuals with clinical and developmental disorders, including autism spectrum disorder (ASD), schizophrenia, bipolar disorder, and anxiety disorders. We are interested in understanding disease mechanisms related to specific disorders vs. dimensional measures, such as cognitive abilities as well as symptom severity across psychiatric diagnoses and healthy populations. In applying this knowledge we strive to study and develop individualized, targeted engagement with specific interventions (personalized medicine).

Primary areas of interest include:

1. Social and emotional cognitive processes, including emotion regulation.

2. Neural mechanisms underlying severe psychiatric disorders, including ASD and schizophrenia.

3. Applying advanced neuroimaging analysis methods, such as dynamic functional connectivity and machine learning, to understanding heterogeneity in behavioral phenotypes and their underlying neural mechanisms.

4. Translational research - applying knowledge about disease mechanisms toward understanding behavioral and pharmacological treatments for neural target engagement.

Current Research:

Neural Architecture of Social Emotional Processing and Regulation in Autism Spectrum Disorder: A Dynamic Connectivity Perspective

AM-FM People
Michal Assaf
Christopher Hyatt, PhD
Alycia Nicholson
Olivia Grella
Godfrey Pearlson, MD
Gretchen Diefenbach, PhD
Mirjana Domakonda, MD
Vince Calhoun, PhD
Bruce Wexler, MD
Silvia Corbera, PhD
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