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Current Studies
Healthy Adults With and Without a Family History of Alcoholism

What is this research about?
This project explores the effects of Saracatinib on alcoholism risk-relevant tasks with regard to reward and impulsivity behavior. Saracatinib is an investigational medication that has been studied in patients with memory problems as well as healthy volunteers, but is believed to have a role in alcoholism therapy. This study provides the opportunity to advance our understanding of specific aspects of brain function related to familial alcoholism.

Who can participate?
If you or someone you know would be interested in participating, we are looking for healthy individuals who:

  • Have family members with a drinking problem OR have no family history of alcoholism.

  • Are right handed

  • Are between the ages of 18 -40

What does the study involve?
The research study consists of three separate days: one 8 hour screening visit, as well as two research visits each lasting approximately 6 ½ - 7 hours. Each research visit you will be administered either a placebo or 125 mg dose of Saracatinib. Transportation will be provided to and from the study on each of the research visits.

Qualified participants will complete:

  • An interview with trained staff

  • Neuropsychological testing, which consists of tests that measure cognitive abilities such as memory, impulsivity and other thought processes

  • Questionnaires about impulsivity, personality, drinking habits, and more

  • Safe and non-invasive fMRI scans

  • Safe and non-invasive EEGs

  • An optional non-invasive saliva sample for genetic testing

  • A blood draw and EKG on each visit to ensure health prior to and during participation in the study

Participants will help us advance our understanding of brain function in those with and without family histories of alcoholism.

Participants are compensated $20 an hour for the time that they participate, plus additional small amounts of money for scoring well on some of the tasks. Upon completion of all four study sessions, participants will also be given a $50 gift card to Target. Additionally, lunch will be provided on each of the three research visits.

How do I participate?
If you are interested in participating, or have any questions regarding this research study, you can call or text 475.414.1595.

You can also fill out our online survey to determine if you are eligible to participate: https://survey.az1.qualtrics.com/jfe/form/SV_eJcxubius2ZqZQ9

Links
Research Update
(Real Player required)
Presentation at Yale 11/5/04
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