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The People of the Olin Neuropsychiatric Research Center

The People of the Olin Neuropsychiatry Research Center

Shashwath Meda
Imaging Analyst
Olin Neuropsychiatry Research Center

200 Retreat Avenue
Whitehall Building - Institute of Living
Hartford CT 06106
Phone: 860-545-7700, ext 7804

Shashwath's CV


Who Am I?

Shashwath Meda completed his Bachelor of Engineering in Electrical and Electronics from India. Following his Bachelors he obtained an advanced degree in Biomedical Engineering from Wayne State University (Michigan) in 2005. During his graduate career, he was part of the MR Research Facility (Detroit Medical Center) involved in active research on presurgical functional mapping and development of novel MR biomarkers for TBI (Traumatic Brain Injury), under the dual mentorship of Dr. E. Mark Haacke and Dr. Randall. R. Benson.

Early 2006 he joined The Olin Neuropsychiatry Research Center and currently holds the position of a senior clinical data analyst. As part of his job he serves as a liaison between PI�s and multiple projects involving complex data/imaging analysis. His major interests include 1) Assessing genotype-phenotype relationships using univariate and multivariate imaging techniques in psychiatric populations 2) Connectivity analysis in cohorts with major neuropathology 3) Exploring brain function and morphology in substance abuse groups.

Currently Active Projects

  • Identifying the role of genes on brain function and morphology in healthy, substance abuse and other psychiatric illnesses.
  • Influence of alcohol on driving - Investigating the functional brain circuitry and localization using ICA and SPM.


Harford Hospital New investigator grant - Characterizing the Dyslexia Phenotype using Genetics and MR Morphology 
Role: Primary Investigator


Meda S.A., Stevens M.C., Potenza M.D., Pittman B., Gueorguieva R., Andrews M.M., Thomas A.D., Muska C., Hylton J.L & Pearlson G.D. (2009) Investigating the Behavioral and Self-Report Constructs of Impulsivity Domains using Principal Component Analysis. Behavioral Pharmacology-In Press

Allen, A. J., Meda, S. A., Skudlarski, P., Calhoun, V. D., Astur, R. S., Ruopp, K., & Pearlson, G. D. (2009) Effects of alcohol on performance on a distraction task during simulated driving. Alcohol Clin Exp Research, 33(4):617-25.

Meda, S. A., Bhattarai, M., Morris, N. A., Astur, R. S., Calhoun, V. D., Mathalon, D. H., Kiehl, K. A., & Pearlson G. D. (2008). An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients. Schizophr Res, 104(1-3), 85-95.

Meda, S. A., Calhoun, V. D., Astur, R. S., Turner, B. M., Ruopp, K., & Pearlson, G. D. (2008). Alcohol dose effects on brain circuits during simulated driving: An fMRI study. Hum Brain Mapp., 30(4): 1257-70.

Meda, S. A., Giuliani, N. R., Calhoun, V. D., Jagannathan, K., Schretlen, D. J., Pulver, A., Cascella, N., Keshavan, M., Kates, W., Buchanan, R., Sharma, T., & Pearlson, G. D. (2008). A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry. Schizophr Res, 101(1-3), 95-105.

Meda, S.A., Gelernter, G., Gruen, J.G., Calhoun, V. D., Meng, H., Cope, N.A & Pearlson, G. D (2008). Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals. Brain Imaging and Behav, 2, 21-26.

Skelly, L. R., Calhoun, V., Meda, S. A., Kim, J., Mathalon, D. H., & Pearlson, G. D. (2008). Diffusion tensor imaging in schizophrenia: relationship to symptoms. Schizophr Res, 98(1-3), 157-162.

Benson, R. R., Meda, S. A., Vasudevan, S., Kou, Z., Govindarajan, K. A., Hanks, R. A., Mills, S. R., Makki, M., Latif, Z., Coplin, W., Meythaler, J., & Haacke, E. M. (2007). Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury. J Neurotrauma, 24(3), 446-459.

Meda, S. A., Stevens, M. C., Folley, B. S., Calhoun, & Pearlson, G. D. Evidence for anomalous network connectivity during working memory in schizophrenia (Under Review � Schizophrenia Research)

Parker, B. A., Thompson, P. D., Ruopp, K. C., Meda, S. A., Grimaldi, A. S., & Pearlson, G. D. Exercise training alters hippocampal activity and function in humans (Under Review � Medicine and science in sports and exercise)

Andrews M.M., Meda S.A., Thomas A.D., Potenza M.D., Krystal J.H., Worhunsky P., Stevens M.C., O� Malley S., Book G., & Pearlson G.D. Individuals Family History Positive for Alcoholism Show fMRI Abnormalities in Reward Sensitivity, Related to Impulsivity Factors (Under Review � Archives of General Psychiatry)

Rzepecki C.I., Meda S.A., Calhoun V.D., Stevens M.C., Jafri M.J., Astur R.S., & Pearlson G.D. Disruptions in Functional Neural Connectivity During Drunk Driving. (Under Review � Alcohol Clinical Experimental Research)

Lui S., Li T., Deng W., Jiang L., Wu Q., Tang H., Yue Q., Wei Y., Huang X., Collier D.A., Meda S.A., Pearlson G.D., Mechelli A., Sweeney J.A., & Gong Q. Short-term effect of antipsychotic treatment on cerebral function in drug-na�ve first episode schizophrenia revealed by rfMRI at 3T. (Under Review � Nature Neuroscience)

Parker, B. A., Thompson, P. D., Ruopp, K. C., Meda, S. A., Grimaldi, A. S., & Pearlson, G. D. Changes in memory function and neuronal activation associated with atorvastatin therapy (Under Review � Pharmacotherapy)

Meda, S. A., Jagannathan K., Gelernter, J., Calhoun V.D., Liu J.,Stevens, M. C., & Pearlson, G. D. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schziophrenia (Under Review � Neuroimage)

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