Godfrey Pearlson, M.D.
Veroff AE, Pearlson GD, and Ahn
HS: CT scan and neuropsychological correlates of Alzheimer's disease and Huntington's
disease. Brain and Cognition, 1:177-184, 1982.
Pearlson GD and Tune LE. Cerebral
ventricular size and cerebrospinal fluid acetylcholinesterase levels in senile
dementia of the Alzheimer Type. Psychiatry Research, 17:23-29, 1986.
Pearlson GD, Ross CA, Lohr WD,
Rovner BW, Tune LE, and Folstein MF: Family history of affective disorder
is associated with the depressive syndrome of Alzheimer's disease. American
Journal of Psychiatry, 147:452-456, 1990.
Pearlson GD, and Ross CA: (ltr.
to ed.) Family history of depression and alcoholism in Alzheimer patients
and age-matched controls. International Journal of Geriatric Psychiatry. 5:344-345,
Aylward EA, Karagiozis H, Pearlson
G, and Folstein MF: Suprasellar cistern measures as a reflection of dementia
in Alzheimer's disease but not Huntington's disease. Journal of Psychiatric
Research, 25:31-47, 1991.
Tune LE, Brandt J, Frost JJ, Harris
G, Mayberg H, Steele C, Burns A, Sapp J, Folstein MF, Wagner HN, and Pearlson
GD. Physostigmine in Alzheimer's disease: effects on cognitive functioning,
cerebral glucose metabolism analyzed by positron emission tomography and cerebral
blood flow analyzed by single photon emission tomography. Acta Psychiatr Scand:
Supplement 366:61-65, 1991.
Rabins PV, Pearlson GD, and Aylward
EH. Magnetic resonance imaging in the diagnosis of dementia. (ltr. to ed.).
American Journal of Psychiatry, 149:419, 1992.
Pearlson GD, Harris GJ, Powers
RE, Barta PE, Camargo EE, Chase GA, Noga JT, and Tune LE. Quantitative changes
in mesial temporal volume, regional cerebral bloodflow and cognition in Alzheimer's
disease. Archives of General Psychiatry, 49:402-408, 1992.
Aylward EH, Rasmusson DX, Brandt
J, Raimundo L, Folstein M, and Pearlson GD. CT measurement of suprasellar
cistern predicts rate of cognitive decline in Alzheimers disease. Journal
of the International Neuropsychological Society, 2:89-95, 1996.
Hooten WM, and Pearlson GD. Delirium caused by tacrine and ibuprofen interaction. (ltr. to the ed.) American Journal of Psychiatry. 153:6, 1996.
Lyketsos CG, Tune LE, Pearlson
GP, and Steele C. Major depression in Alzheimers disease. An interaction
between gender and family history. Psychosomatics. 37:380-384, 1996.
Barta PE, Pearlson GD, Powers RE, Aylward EH, Chase GA, Harris GJ, Rabins PV, Raimundo LD, and Tune LE. Quantitative MRI volume changes in late-onset schizophrenia and Alzheimers disease compared to normal controls. Psychiatry Research - Neuroimaging. (In Press.)
Pearlson GD, and Veroff AE: Computerized
tomographic scan changes in manic-depressive illness. Lancet, 8244, II:470
Lipsey JR, Robinson RG, Pearlson
GD, Rao K, and Price TR: Mood change following bilateral hemisphere brain
injury. British Journal Psychiatry, 293:241-250, 1983.
Pearlson GD, Garbacz DJ, Tompkins
RH, Ahn HS, Gutterman DF, and DePaulo JR: Lateral ventricular enlargement
in affective disorder: Clinical correlates. American Journal of Psychiatry,
Pearlson GD, Garbacz DJ, Breakey
WR, Ahn HS, and DePaulo JR: Relationship of lateral ventricular enlargement
on CT scan to chronic unemployment in schizophrenia and affective disorder.
Psychiatry Research, 12:1-9, 1984.
Lipsey JR, Robinson RG, Pearlson
GD, Rao K, and Price TR: Nortriptyline treatment of post stroke depression:
A doubleblind treatment trial. Lancet, I:297-300, 1984.
Robinson RG, Lipsey JR, and Pearlson
GD: The occurrence and treatment of post-stroke mood disorders. Comprehensive
Therapy, 10:19-24, 1984.
Lipsey JR, Robinson RG, Pearlson
GD, Rao K, and Price TR: The dexamethasone suppression test and mood following
stroke. Am. J. Psychiatry, 142:318-323, 1985.
Wong DF, Wagner HN, Jr., Pearlson
GD, Dannals RF, and Tune LE: Dopamine receptor binding of C-11 N Methylspiperone
in the caudate in schizophrenia and bipolar illness: A preliminary report.
Psychopharmacology Bulletin, 21:595-598, 1985.
Robinson RG, Lipsey JR, Bolla-Wilson
K, Bolduc PL, Pearlson GD, Rao K, and Price TR. Mood disorders in left-handed
stroke patients. Am. J. Psychiatry, 142:1424-1429, 1985.
Starkstein SE, Pearlson GD, Boston
J, and Robinson RG: Mania after brain injury: A controlled study of etiological
factors. Archives of Neurology. 44:1069-1073, 1987.
Aylward EH, Roberts-Twillie JV,
Barta PE, Kumar AJ, Harris GJ, Geer M, Peyser CE, and Pearlson GD. Basal ganglia
volumes and white matter hyperintensities in bipolar disorder. American Journal
of Psychiatry, 151:687-693, 1994.
Pearlson GD, Wong DF, Tune LE,
Ross CA, Chase GA, Links JM, Dannals RF, Wilson AA, Ravert HT, Wagner HN,
Jr, and DePaulo JR: C-11 NMSP PET scans in psychotic and non-psychotic bipolars.
Archives of General Psychiatry, 52:471-477, 1995.
Wong DF, Pearlson GD, Tune LE, Young LT, Young D, Cidis-Meltzer C, Wilson PD, Chan B, Dannals RF, Ravert HT, Ross CA, Kuhar MJ, and Gjedde A. Quantification of D2 Dopamine Receptors in Living Human Brain III: Normal Aging, Schizophrenia and Bipolar Illness: Density Measurements and Validation. Journal of Cerebral Blood Flow and Metabolism, (In Press).
Down Syndrome - Autism:
Pearlson GD, Warren A: Brain atrophy
in aging Down's syndrome patients. (ltr. to ed.) Neurology, 39:1407-1408,
Pearlson GD, Warren A, Starkstein
SE, Aylward EH, Kumar AJ, Chase GA, Folstein MF: Brain atrophy in 18 patients
with Down's syndrome. American Journal of Neuro-Radiology, 11:811-816, 1990.
Piven J, Berthier ML, Starkstein
SE, Nehme E, Pearlson GD, Folstein SE: Magnetic resonance imaging evidence
for a defect in cerebral cortical development in autism. American Journal
of Psychiatry, 147:734-739, 1990.
Piven J, Nehme E, Simon J, Barta
P, Pearlson G, Folstein SE. Magnetic resonance imaging in autism: Measurement
of the cerebellum, pons and fourth ventricle. Biological Psychiatry, 31: 491-504,
Habbak R, Warren A, Aylward E,
Jerram M, Pearlson G. Synkinesias are common in Down syndrome. Journal of
Nervous and Mental Disease, 182:667, 1994.
Holder JL, Habbak RA, Pearlson
GD, Aylward EA, Pulsifer M, Warren AC. Reduced survival of apolipoprotein
E4 homozygotes in Downs syndrome? NeuroReport, 1996.
Aylward E, Habbak R, Warren A, Pulsifer MB, Barta PE, Jerram M, Pearlson GD. Cerebellar volume in adults with Down Syndrome. Archives of Neurology, 54:209-212, 1997.
Normal Aging - Sex Differences:
Harris GH, Schlaepfer TE, Peng
LW, Lee S, Federman EB, Pearlson GD: Magnetic resonance imaging evaluation
of the effects of ageing on grey-white ratio in the human brain. Neuropathology
and Applied Neurobiology, 20:290-293, 1994.
Schlaepfer TE, Harris GJ, Aylward EH, McArthur HC, Peng LW, Lee S, Pearlson GD. Structure differences in the cerebral cortex of normal male and female subjects. Psychiatry Research - Neuroimaging, 61:129-135, 1995.
Neuro-Imaging Methods / Reviews
Pearlson GD, Veroff AE, Wise TN.
The using of CT scanning in psychiatry. Psychosomatics, 23:993-1004,1982.
Pearlson GD, Garbacz DJ, Tompkins
RH. Imaging of the brain: Aiding the search for physical correlates of mental
illness. Integrative Psychiatry, 1:134-138, 1983.
Harris GJ, Rhew EH, Noga JT, Pearlson
GD. A user-friendly method for rapid brain and CSF volume calculation using
transaxial MRI images. Psychiatry Research Brain Imaging, 40:61-68, 1991.
Aylward EH, Schwartz J, Machlin
SR and Pearlson GD. Bicaudate ratio as a measure of caudate volume in MRI.
American Journal of Neuroradiology, 12:1217-1222, 1991.
Harris GJ, Links JM, Pearlson
GD, Camargo EE. Cortical circumferential profiles: An objective approach to
the analysis of the distribution of radioactivity in cerebral emission computed
tomography. Application to a study of Alzheimer's disease. Psychiatry Research:
NeuroImaging, 40:167-180, 1991.
Harris GJ, Pearlson GD. MRI-guided
region of interest placement on emission computed tomograms. Psychiatry Research:
Neuro-Imaging, 50:57-63, 1993.
Harris GJ, Barta PE, Peng L, Lee
S, Brettschneider PD, Shah A, Henderer JD, Pearlson GD. MRI gray and white
matter volume segmentation using manual thresholding: dependence on image
brightness. American Journal Neuroradiology, 15:225-230, 1994.
Barta PE, Petty RG, McGilchrist
I, Lewis RW, Jerram M, Casanova MF, Powers RE, Brill, III LB, Pearlson GD.
Asymmetry of the planum temporale: Methodologic considerations. Psychiatry
Research Neuroimaging, 61:137-150, 1995.
Wong DF, Tune LE, Shaya EK, Pearlson GD, Dannals RF, Ravert HT, Gjedde A. Quantification of neuroreceptors in living human brain V: comparing D2 dopamine receptor densities as measured with [11C]Raclopride and [11C]NMSP. Journal of Cerebral Blood Flow and Metabolism (In Press).
Starkstein SE, Brandt J, Folstein
SE, Strauss ME, Berthier ML, Pearlson GD, Wong DF, McDonnell A, Folstein MF.
Neuropsychological and neuroradiological correlates in Huntington's disease.
Journal Neurology, Neurosurgery and Psychiatry, 51:1259-1263, 1988.
Starkstein SE, Folstein SE, Brandt
J, Pearlson GD, McDonnell A, Folstein MF: Brain atrophy in Huntington's disease.
NeuroRadiology, 31:156-159, 1989.
Harris GJ, Pearlson GD, Peyser
C, Aylward E, Folstein SE. Putamen volume measured on MRI completely discriminates
early Huntington's disease patients from controls. Annals of Neurology, 31:69-75,
Harris GJ, Aylward EH, Peyser
CE, Pearlson GD, Brandt J, Roberts-Twillie JV, Folstein SE. Single photon
emission computed tomographic blood flow and magnetic resonance volume imaging
of basal ganglia in Huntingtons disease. Archives of Neurology 53:316-324,
Aylward EH, Li Q, Stine OC, Ranen
N, Sherr M, Barta PE, Bylsma FW, Pearlson GD, Ross CA. Longitudinal change
in basal ganglia volume in patients with Huntingtons disease. Neurology,
Aylward E, Codori AM, Barta PE, Pearlson GD, Harris G, Brandt J. Basal ganglia volume and proximity to onset in presymptomatic Huntingtons disease. Archives of Neurology, 53:1293-1296, 1996.
Geriatric Depression and Late-Onset
Pearlson GD, McHugh PR: Significance
of enlarged lateral ventricles, (ltr. to ed.) Psychosomatics, 25:707, 1984.
Rabins PV, Pearlson GD, Jayaram
G, Steele CS, Tune LE: Elevated VBR in late-onset schizophrenia. American
Journal of Psychiatry, 144:1216-1218, 1987.
Jeste DV, Harris MJ, Pearlson
GD, Rabins PV, Lesser I, Miller B, Coles C, Yassa R: Late Onset Schizophrenia
- Studying Clinical Validity. Psychiatric Clin. N. America, Psychosis and
Depression in the Elderly, 11:1-13, 1988.
Pearlson GD, Rabins PV: The Late
onset psychoses - possible risk factors. Psychiatric Clin. N. America, Psychosis
and Depression in the Elderly, 11:15-33, 1988.
Pearlson GD, Rabins PV, Kim WS,
Speedie LJ, Moberg PJ, Burns A, and Bascom MJ: Structural brain CT changes
and cognitive deficits in elderly depressives with and without reversible
dementia. Psychological Medicine, 19:573-584, 1989.
Pearlson GD, Kreger L, Rabins
PV, Chase GA, Cohen B, Wirth JB, Schlaepfer TB, Tune LE: Late life onset schizophrenia:
A chart review study. American Journal of Psychiatry, 146:1568-1574, 1989.
Speedie L, Rabins PV, Pearlson
GD, Moberg P: Confrontation naming deficit in dementia of depression. J. Neuropsychiatry
& Clinical Neurosciences, 2:59-63, 1990.
Pearlson GD, Rabins PV (ltr. to
ed.) Late-life onset schizophrenia. American Journal of Psychiatry, 147:1383,
Pearlson GD, Rabins PV, Burns A. CT changes in centrum semiovale white matter in dementia of depression. Psychological Medicine, 21:321-328, 1991.
Rabins PV, Pearlson GD, Aylward
EH, Kumar AJ, Dowell K. Cortical MRI changes in elderly inpatients with major
depression. American Journal of Psychiatry, 148:617-620, 1991.
Pearlson, GD, Tune LE, Wong DF,
Aylward EH, Barta PE, Powers RE, Chase GA, Harris GJ, Rabins PV. Quantitative
D2 dopamine receptor PET and structural MRI changes in late onset schizophrenia.
Schizophrenia Bulletin, 19:783-795, 1993.
Rabins PV, Aylward E, Holroyd S, Chase GA, Pearlson GD. MRI findings differentiate between late-onset schizophrenia and late-life mood disorder. Journal of Nervous and Mental Disease, In Press.
Non AD-HD Dementias (AIDS, MS)
Rabins PV, Brooks BR, O'Donnell
P, Pearlson GD, Moberg PJ, Jubelt B, Coyle P, Dalos N, Folstein MF: Structural
brain correlates of emotional and cognitive disorder in multiple sclerosis.
Brain, 109:585-597, 1986.
LaFrance ND, Pearlson GD, Schaerf
FW, McArthur JC, Polk BF, Links JM, Bascom MJ, Knowles MC, Galen SS. Iodine-123
single photon emission computed tomography in HIV-related dementia. Advances
in Functional Neuro-Imaging, 1:9-15, 1988.
Aylward EH, Henderer JD, McArthur
JC, Brettschneider PD, Harris GJ, Barta PE, and Pearlson GD. Reduced basal
ganglia volume in HIV-1 associated dementia complex: results from quantitative
neuroimaging. Neurology, 43:2099-3104, 1993.
Harris GJ, Pearlson GD, McArthur
JC, Zeger S, LaFrance ND. Altered cortical blood flow in HIV seropositive
individuals with and without dementia: A SPECT study. AIDS, 8:495-499 1994.
Aylward E, Brettschneider PD,
McArthur JC, Harris GJ, Schlaepfer TE, Henderer JD, Barta PE, Tien AY, Pearlson
GD. MRI gray matter volumes reductions in HIV-1 dementia. American Journal
of Psychiatry, 152:987-994, 1995.
Davison SE, Aylward EH, McArthur JC, Selnes O, Lyketsos C, Barta PE, Pearlson GD. A quantitative MRI study of the basal ganglia in depression with HIV infection. Journal of Neuro-AIDS, 1:29-41, 1996.
Hoehn-Saric R, Harris GJ, Pearlson
GD, Cox CS, Machlin SR, and Camargo EE. A fluoxetine induced frontal lobe
syndrome in an obsessive-compulsive patient. J Clinical Psychiatry, 52:131-133,
Machlin S, Harris GJ, Pearlson
GD, et al. Elevated frontal cerebral blood flow in obsessive-compulsive patients:
A SPECT study. American Journal of Psychiatry, 148:1240-1242, 1991.
Hoehn-Saric R, Pearlson GD, Harris
GJ, et al. Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive
disorder. American Journal of Psychiatry, 148:1243-1245, 1991.
Tien AY, Pearlson GD, Machlin
SR, Bylsma RW, Hoehn-Saric R. Oculomotor performance in obsessive compulsive
disorder. American Journal of Psychiatry, 149:641-646, 1992.
Harris GJ, Pearlson GD, Hoehn-Saric
R. Caudate nucleus in obsessive-compulsive disorder patients appears structurally
and functionally normal using MRI and SPECT (Ltr. to ed.). Archives of General
Psychiatry, 50:498-499, 1993.
Harris GJ, Hoehn-Saric RH, Lewis
R, Pearlson GD, Streeter G: Mapping of SPECT regional cerebral perfusion abnormalities
in obsessive-compulsive disorder. Human Brain Mapping, 237-248, 1994.
Aylward EH, Harris GH, Hoehn-Saric R, Barta PE, Machlin S, Pearlson GD. Normal caudate nucleus in obsessive compulsive disorder assessed by quantitative neuro-imaging. Archives of General Psychiatry, 53:577-584.
Drugs of Abuse
Slavney PR, Rich G, Pearlson GD,
and McHugh PR: Phencyclidine abuse and symptomatic mania. Biological Psychiatry,
Pearlson GD: Psychiatric and medical
syndromes associated with phencyclidine (PCP) abuse. Johns Hopkins Medical
Journal, 148:25-33, 1981.
Foltin RW, Fischman MW, Pedroso
JJ, Pearlson GD: Marijuana and cocaine interactions in humans: Cardiovascular
consequences. Pharmacology and Biochemical Behavior, 28:459-464, 1987.
Foltin RW, Fischman MW, Pedroso
JJ, Pearlson GD: Repeated intranasal cocaine administration: Lack of tolerance
to pressor effects. Drug & Alcohol Dependence, 22:169-177, 1988.
Pearlson GD, Fischman MW, Foltin
RW, Cornell E and Pedroso JJ: Cocaine-induced delirium versus delusional disorder.
Biological Psychiatry, 26:847-858, 1989.
Fischman MW. Foltin RW, Nestadt
G and Pearlson GD: Effects of desipramine maintenance on cocaine self-administration
in humans. Journal of Pharmacology and Experimental Therapeutics, 253:760-770,
Cascella N, Pearlson GD, Wong
DF, Brousolle E, Nagoshi C, Margolin RA, London ED: Effects of substance abuse
on ventricular and sulcal measures assessed by computed tomography. British
Journal of Psychiatry, 159:217-221, 1991.
Pearlson GD, Jeffery P, Harris
GJ, Ross CA, Fischman M, Camargo EE. Local cocaine-induced cerebral bloodflow
changes: Correlation with subjective effects. American Journal of Psychiatry,
Schlaepfer TE, Pearlson GD. Pitfalls
of SPECT studies of acute ethanol-induced changes in cerebral blood flow.
(Ltr. to the Editor) American Journal of Psychiatry, 152:111, 1995.
Schlaepfer TE, Strain EC, Bigelow
GE, Lancaster E, Preston KL, Pearlson GD. Differential cerebral blood flow
effects caused by mu versus kappa opioid agonists. NIDA Res Monogr, 162:194,
Schlaepfer TE, Pearlson GD, Wong DF, Marenco S, Dannals RF. Intravenous cocaine competes with [11C]-raclopride at dopamine receptors in human subjects: A PET study. American Journal of Psychiatry. (In Press.)
Schlaepfer TE, Strain E, Pearlson GD, Greenberg B, Lancaster E. Preston K, Bigelow G. Mu vs. kappa receptor agonists - A SPECT rCBF study. American Journal of Psychiatry. (In Press.)
Parkin JM, Sykes P, Pearlson GD.
Energy intake and physical activity in obese children. British Medical Journal,
Pearlson GD, Flournoy LH, Simonson M, Slavney PR. Body image in obese adults. Psychological Medicine, 11:147-154, 1981.
Lateralization of Behavior
Pearlson GD and Robinson RG: Suction
lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral
and catecholaminergic responses. Brain Research,
Kubos KL, Pearlson GD, Robinson
RG: Intracortical kainic acid induces an asymmetrical behavioral response
in the rat. Brain Research, 239:303-309, 1982.
Pearlson GD, Kubos KL, Robinson
RG: Effects of anterior-posterior lesion location on the asymmetrical behavioral
and biochemical response to cortical suction ablations in the rat. Brain Research,
Moran TH, Zern KA, Pearlson GD,
Kubos KL, Robinson RG: Cold water stress abolishes hyperactivity produced
by cortical suction lesions without altering NE depletions. Behavioral Neuroscience,
Moberg PJ, Pearlson GD, Folstein SE, Speedie LJ, Lipsey JR: Olfactory recognition: Differential impairments in early and late Huntington's and Alzheimer's diseases. Journal of Clinical & Experimental Neuropsychology, 9:650-664, 1987.
Pearlson GD, and Robinson RG:
Lateralization of behavioral or emotional responses in intact and hemisphere-damaged
rats and humans. In Isaacson RL, Spear NE (eds): The Expression of Knowledge,
Plenum Press, 1982.
Brady JV, Griffin RR, Heinz RD,
Bigelow GE, Emurian HH, Lukas SE, Ator NA, Nellis MJ, Ray RL, Pearlson GD,
Liebson R, Funderbirk F, Jasinski DR, Henningfield J and Johnson RE: Abuse
Liability and Behavioral Toxicity Assessment. N.I.D.A. 1983.
Pearlson GD, Coyle JT: The dopamine
hypothesis and schizophrenia. In Coyle JT, Enna S (Eds): Neuroleptics: Neurochemical,
Behavioral and Clinical Perspectives: Vol III, CNS Pharmacology, New York,
Raven Press; 1983; 297-324.
Pearlson GD, Coyle JT: Schizophrenic
Disorders. In Harvey M and Johns RJ. (Eds.) Principles and Practice of Medicine,
22nd Ed., New York, Appleton, Century Crofts, 1987.
Pearlson GD, Garbacz DJ, Tompkins
RH, Ahn HS, Rabins PV: Lateral cerebral ventricular size in late onset schizophrenia.
In Miller, N. E. (Ed): Paranoia and Schizophreniform Disorders in Late Life;
Pearlson GD, Strain E. Chronic
pain and depression. In Robinson RG and Rabins PV (Eds), Depression in Medical
Illness, Igaku-Shoin, New York, 1989.
Rabins PV, Pearlson GD, Strauss
ME: Dementia and Pseudodementia in classic psychiatric syndromes. In Whitehouse
P (Ed), Dementia, Contemporary Neurology Series, F.A. Davis, Philadelphia,
Pearlson GD, Marsh L. MRI in Psychiatry.
APA 12th Annual Review of Psychiatry, 12:347-382, 1993.
Burns A, Pearlson GD. CT in Alzheimer's
Disease. In R. Levy, A. Burns Eds., Dementia, 1994.
Rabins PV, Pearlson GD. Depressive
Dementia in R. Levy, A. Burns Ed., Dementia, 1994.
Rabins PV and Pearlson GD: Late
onset paranoid disorders: Issues requiring answers; (b) Paraphrenia or schizophrenia?
In Chiu E (ed.). Functional Psychiatric Disorders in the Elderly. Cambridge,
U.K., Cambridge University Press, 1994.
Pearlson GD, Petty R. Late Life
Onset Schizophrenia, in Cummings J and Coffey CE (eds.), Textbook of Geriatric
Neuropsychiatry, APA Press, 1994.
Pearlson GD (Section Editor),
Section on Neuropsychiatry. In Coffey CE and Cummings J (Eds), Pearlson GD
and Lovell M (Assoc. Editors), Textbook of Geriatric Neuropsychiatry, American
Psychiatric Press, 1994.
Pearlson GD. Structural Imaging
in Dementia. In Lewis SW and Higgins NP (Eds.) Brain Imaging in Psychiatry,
Blackwell Scientific Press, Oxford UK, 1997.
Pearlson GD and Schlaepfer TE.
Brain imaging in affective disorders. In Meltzer H, et al., Psychopharmacology:
A Fourth Generation of Progress, Raven Press, NY, 1019-1028, 1995.
Pearlson GD and Schlaepfer TE. Brain imaging in affective disorders. In Meltzer H, et al., Psychopharmacology. A Fifth Generation of Progress, Raven Press, NY, 1997.
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